PittsburghV1, Main, Exploration, bibRecord, 00A717

Immunity against Cyclin B1 Tumor Antigen Delays Development of Spontaneous Cyclin B1‐Positive Tumors in p53−/− Mice

Identifieur interne : 00A717 ( Main/Exploration ); précédent : 00A716; suivant : 00A718

Immunity against Cyclin B1 Tumor Antigen Delays Development of Spontaneous Cyclin B1‐Positive Tumors in p53−/− Mice

Auteurs : Laura A. Vella [États-Unis] ; Min Yu [États-Unis] ; Amy B. Phillips [États-Unis] ; Olivera J. Finn [États-Unis]

Source :

Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2009-09.

RBID : ISTEX:041B0040891D70751988E29D51769B13AF7CE5A5

Descripteurs français

Wicri :
- topic : Vaccination, Vaccin.

English descriptors

Abstract

We previously identified cyclin B1‐specific T cells and antibodies in cancer patients with cyclin B1‐positive (+) tumors and also in some healthy individuals. We also demonstrated that these responses may be important in cancer immunosurveillance by showing that vaccination against cyclin B1 prevents growth of transplantable cyclin B1+ tumors in mice. Constitutive overexpression of cyclin B1 was determined to correlate with the lack of p53 function. This allowed us to use p53−/− mice as a model that better approximates human disease. These p53−/− mice spontaneously develop cyclin B1+ tumors. At 5–6 weeks of age, when the mice were still healthy with no evidence of tumor, they received the cyclin B1 vaccine and were then observed for tumor growth. We demonstrate that cyclin B1 vaccination delays spontaneous cyclin B1+ tumor growth and increases median survival of tumor‐bearing p53−/− mice.

Url:

https://api.istex.fr/document/041B0040891D70751988E29D51769B13AF7CE5A5/fulltext/pdf

DOI: 10.1111/j.1749-6632.2009.04941.x

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream Istex, to step Checkpoint: 001E99
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to stream Main, to step Curation: 00A717

Le document en format XML

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<front><div type="abstract" xml:lang="en">We previously identified cyclin B1‐specific T cells and antibodies in cancer patients with cyclin B1‐positive (+) tumors and also in some healthy individuals. We also demonstrated that these responses may be important in cancer immunosurveillance by showing that vaccination against cyclin B1 prevents growth of transplantable cyclin B1+ tumors in mice. Constitutive overexpression of cyclin B1 was determined to correlate with the lack of p53 function. This allowed us to use p53−/− mice as a model that better approximates human disease. These p53−/− mice spontaneously develop cyclin B1+ tumors. At 5–6 weeks of age, when the mice were still healthy with no evidence of tumor, they received the cyclin B1 vaccine and were then observed for tumor growth. We demonstrate that cyclin B1 vaccination delays spontaneous cyclin B1+ tumor growth and increases median survival of tumor‐bearing p53−/− mice.</div>
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Immunity against Cyclin B1 Tumor Antigen Delays Development of Spontaneous Cyclin B1‐Positive Tumors in p53−/− Mice

Immunity against Cyclin B1 Tumor Antigen Delays Development of Spontaneous Cyclin B1‐Positive Tumors in p53−/− Mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri